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Register-based cohort study

Living longer with HIV — but living well?

COSMOHS is a nationwide Swedish cohort study on health, comorbidity and health-related quality of life among people living with HIV.

COSMOHS logotype

Thanks to modern antiretroviral therapy, life expectancy for people living with HIV is close to that of people without HIV, and those who reach good immune recovery early after starting treatment appear to have a life expectancy similar to people without HIV. But living longer is not the same as living well. Studies show that people living with HIV develop other conditions more often, and spend fewer of their years in good health, than the rest of the population. How much of that extra risk comes from HIV itself is still an open question.

COSMOHS — the Cohort Study on Morbidity and HIV in Sweden — was set up to answer it. By linking the Swedish nationwide HIV quality register InfCareHIV to Sweden's national health and population registers, we can follow health outcomes for people with and without HIV across more than 40 years, while accounting for age, sex, country of birth, socioeconomic situation and other comorbidities.

The study in numbers

~9 million
people in the control study population
40+ years
of follow-up, from 1982 onwards — the end year is updated at each new register linkage
> 99 %
of everyone diagnosed with HIV in Sweden is included
40 %
of people in active HIV-care are women
2 in 3
of people with HIV were born outside Sweden