Register-based cohort study
Living longer with HIV — but living well?
COSMOHS is a nationwide Swedish cohort study on health, comorbidity and health-related quality of life among people living with HIV.

Thanks to modern antiretroviral therapy, life expectancy for people living with HIV is close to that of people without HIV, and those who reach good immune recovery early after starting treatment appear to have a life expectancy similar to people without HIV. But living longer is not the same as living well. Studies show that people living with HIV develop other conditions more often, and spend fewer of their years in good health, than the rest of the population. How much of that extra risk comes from HIV itself is still an open question.
COSMOHS — the Cohort Study on Morbidity and HIV in Sweden — was set up to answer it. By linking the Swedish nationwide HIV quality register InfCareHIV to Sweden's national health and population registers, we can follow health outcomes for people with and without HIV across more than 40 years, while accounting for age, sex, country of birth, socioeconomic situation and other comorbidities.
The study in numbers
- ~9 million
- people in the control study population
- 40+ years
- of follow-up, from 1982 onwards — the end year is updated at each new register linkage
- > 99 %
- of everyone diagnosed with HIV in Sweden is included
- 40 %
- of people in active HIV-care are women
- 2 in 3
- of people with HIV were born outside Sweden
Explore
Research areas
The sub-projects that make up the study, from cancer and cardiovascular disease to quality of life and stigma.
Open
Method
Data & methods
Which registers are linked, how the linkage is done, and how the data are analysed.
Open
Who we are
People & collaborations
Steering committee, researchers, and the national partners behind the study.
Open